Hyperactive Variants of p38α Induce, whereas Hyperactive Variants of p38γ Suppress, Activating Protein 1-mediated Transcription
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چکیده
منابع مشابه
Hyperactive glycogen synthase mutants of Saccharomyces cerevisiae suppress the glc7-1 protein phosphatase mutant.
A yeast glc7-1 mutant expressing a variant of protein phosphatase type 1 fails to accumulate glycogen. This defect is associated with hyperphosphorylated and inactive glycogen synthase, consistent with Glc7p acting directly to dephosphorylate and activate glycogen synthase. To characterize the glycogen synthesis defect of this mutant in more detail, we isolated 26 pseudorevertants of the glc7-1...
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Mitogen-activated protein kinases (MAPKs) play key roles in differentiation, growth, proliferation, and apoptosis. Although MAPKs have been extensively studied, the precise function, specific substrates, and target genes of each MAPK are not known. These issues could be addressed by sole activation of a given MAPK, e.g., through the use of constitutively active MAPK enzymes. We have recently re...
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Sleeping Beauty (SB) is a prominent Tc1/mariner superfamily DNA transposon that provides a popular genome engineering tool in a broad range of organisms. It is mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends. To facilitate SB's applications, here we determine the crystal structure of the transposase catalytic domai...
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Hyperactive Messages are similar to Active Messages; but they are designed with two goals. Like active messages, Hyperactive Messages facilitate efficient communication among computations distributed over a network of workstations. But they also facilitate for the dynamic insertion of code or upgrades to existing code into a computation. If a Hyperactive Message carries data it is processed as ...
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Attention deficit hyperactive disorder (ADHD) is one of the most common neurological disorders among children with approximately 5.4 million children diagnosed in the United Sates. Inattention and hyperactivity are two major symptoms associated with ADHD interfering with the ability to function well at school or work. The etiology of ADHD is very complex involving genetics, brain structure and ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m608012200